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KMID : 0616620000060020277
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Journal of Soonchunhyang Medical College
2000 Volume.6 No. 2 p.277 ~ p.283
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Agreement of serum priest IgE with specific allergen positivity in allergic patients
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Abstract
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To evaluate usefulness of serum IgE to determine specific allergens, authors conducted priest IgE and MAST-CLA allergen-specific IgE assays in 78 allergic patients diagnosed at Soonchunhyang University Chunan Hospital during October 1998 through July 2000. During the study period, inhalent and food Korean panels were applied in 57 (73.1%) and 21 outpatients (26.9%), respectively. Kappa index was calculated to evaluate the agreement of priest IgE with Total IgE and allergen-specific IgE by MAST-CLA.
1.The mean (±SD) age was 13.2 (±14.1) year-old and male accounted for 62.8%.
2.The overall positive rate of priest IgE was 66.7% and mean (±SD) level of priest IgE was 271.2 (±265.6) IU/ml
3.Patients with more than one specific allergen and with elevated total IgE by MAST-CLA were 25 (32.1%) and 33 (42.3%), respectively.
4.Significant agreement between total IgE and allergen-specific IgE was shown, but strength of agreement was slight (Kappa = 0.186, p = 0.046).
5.While no significant agreement between priest IgE and total IgE was observed, the priest IgE agreed significantly with allergen-specific IgE (Kappa = 0.153, p=0.043).
In conclusion, our data suggested that serum priest IgE is more likely associated with allergen-specific IgE than total IgE in MAST-CLA assay. Furthermore, it is recommended that Korean panel of MAST-CLA should contain more specific allergens.
Key words : Allergy, IgE, Allergen, MAST-CLA
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